| 教授 生物化学系 硕士生导师 Email：jiangjun@scau.edu.cn |
个人简介
蒋珺，已发表SCI论文39篇，其中以第一作者或通讯作者（含同等贡献）在Nucleic Acids Research（IF:19.16），Oncogene（IF:8.756），Molecular & Cellular Proteomics（IF:7.381），Archives of Toxicology（IF:6.168），Biochemical Pharmacology（IF:6.1）等国际知名期刊发表SCI论文14篇；主持国家自然科学基金青年项目、广东省自然科学基金面上项目等课题10项；以学术骨干/核心成员参与973计划子课题、NSFC-广东省联合基金重点项目、广东省自然科学基金研究团队、粤港真菌毒素生物防控团队等多项重点项目；入选广东省高等学校优秀青年教师培养计划、广州市珠江科技新星等人才项目；作为第二完成人获得2021年度第十二届大北农科技奖创新奖；担任中国生物化学与分子生物学会农业分会青年委员会委员，广东省生物化学与分子生物学学会理事以及Chemical Research in Toxicology，Environmental Pollution等知名期刊审稿人。
学习经历
1.2004/09-2009/07，中国科学院水生生物研究所，博士，导师：桂建芳院士
2.2000/09-2004/07，华中师范大学，爱游戏唯一官网，学士
工作经历
1.2022/12至今，爱游戏唯一官网，爱游戏唯一官网，教授
2.2019/09-2020/06，美国加州大学欧文分校，访问学者
3.2011/07-2022/11，爱游戏唯一官网，爱游戏唯一官网，副研究员
4.2011/04-2011/10，香港大学，李嘉诚医学院，高级研究助理
5.2009/07-2011/07，爱游戏唯一官网，爱游戏唯一官网，博士后，合作导师：邓诣群教授
研究方向
1. 畜禽霉菌毒素中毒病的发生发展机制与防控
2. 参与霉菌毒素代谢关键酶的功能、结构与调控
发表论文（*通讯作者，#第一作者）
2024年
1. Zige Wang, Qiang Huang, Feiyong Zhang, Jiajun Wu, Lingling Wang, Yu Sun, Yiqun Deng*, Jun Jiang*, The key role of porcine cytochrome P450 2A19 in the bioactivation of aflatoxin B1 in the liver. Journal of Agricultural and Food Chemistry. 2024 Jan 31;72(4):2334-2346.
2. Jianhong Xia#, Haiyun Wang#, Zhihang Zhong, Jun Jiang*, Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling. Cells. 2024, 13, 953.
2023年
1. Jiahui Zhu, Guihong Li, Qiang Huang, Jikai Wen, Yiqun Deng*, Jun Jiang*. TET3-mediated DNA demethylation and chromatin remodeling regulate T-2 toxin-induced human CYP1A1 expression and cytotoxicity in HepG2 cells. Biochemical Pharmacology. 2023 May; 211:115506.
2. Caizhu Wang#, Ruqin Lin#, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng*, Jikai Wen*. Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells. Biochemical pharmacology. 2023, Aug; 214, 115645.
3. Tianqing Jiang, Xueying Qi, Ruqin Lin, Jun Jiang, Jikai Wen*, Yiqun Deng*. T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1. Ecotoxicology and Environmental Safety. 2023 Jul 1; 259:115028.
4. Danyang Li, Guoqiang Liang, Peiqiang Mu, Jinquan Lin, Jiarun Huang, Chongwen Guo, Yang Li, Ruqin Lin, Jun Jiang, Jun Wu, Yiqun Deng*, Jikai Wen*. Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design. Food Chemistry. 2023 Oct 15; 423:136274.
2022年
1. Xiaoxiao Mao, Jie Li, Xin Xie, Shuang Chen, Qiang Huang, Peiqiang Mu, Jun Jiang*, Yiqun Deng*. Deoxynivalenol induces caspase‑3/GSDME‑dependent pyroptosis and inflammation in mouse liver and HepaRG cells. Archives of Toxicology. 2022 Nov; 96(11): 3091-3112.
2. Yu Sun, Jun Jiang, Peiqiang Mu, Ruqin Lin, Jikai Wen*, Yiqun Deng*. Toxicokinetics and Metabolism of Deoxynivalenol in Animals and Humans. Archives of Toxicology 2022 Oct;96(10):2639-2654. (Invited Review)
3. Lingling Wang, Qiang Huang, Jun Wu, Wanying Wu, Jun Jiang, Hongji Yan, Jieying Huang, Yu Sun, Yiqun Deng*. The metabolism and biotransformation of AFB1: Key enzymes and pathways. Biochemical Pharmacology. 2022 May; 199: 115005. (Invited Review)
4. Xianhui Wen, Xingsheng Sun, Zheyuan Ou, Jun Jiang, Qingmei Chen, Xirong He, Zhangsheng Hu, Han Qiao, Kuan Zhou, Xin Li, Yiqun Deng*, Jikai Wen*. Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration. Acta biochimica et biophysica Sinica. 2022 Oct 25; 54(10): 1441–1452.
2021年
1. Jun Jiang#, Jiahui Zhu#, Qian Liu#, Tingting Zhang, Jikai Wen, Yiqun Deng*. Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene. FASEB Journal. 2021; 35: e21469.
2. Melissa McNeil#, Yingying Han#, Peng Sun, Kazuhide Watanabe, Jun Jiang, Natasha Chen, Zhengquan Yu, Bin Zhou, Xing Dai*. Nfatc1’s Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self‑renewal. Journal of Mammary Gland Biology and Neoplasia. 2021 Dec; 26(4): 357-365.
3. Xi Fu#, Zheyuan Ou#, Mei Zhang, Yi Meng, Yanling Li, Qingmei Chen, Jun Jiang, Xin Zhang, Dan Norbäck, Zhuohui Zhao*, Yu Sun*.Classroom microbiome, functional pathways and sick-building syndrome (SBS) in urban and rural schools - potential roles of indoor microbial amino acids and vitamin metabolites. Science of the Total Environment. 2021 Nov 15; 795: 148879.
2019年
1. Qian Liu, Jikai Wen, Jiahui Zhu, Tingting Zhang, Yiqun Deng*, Jun Jiang*. Aromatic Hydrocarbon Receptor Regulates Chicken Cytochrome P450 1A5 Transcription: A Novel Insight into T-2 Toxin-induced Gene Expression and Cytotoxicity in LMH Cells. Biochemical Pharmacology. 2019 Oct; 168: 319-329.
2. Wenchu Ye, Ruohong Chen, Xiaoxuan Chen, Boyan Huang, Ruqin Lin, Xuan Xie, Jiongjie Chen, Jun Jiang, Yiqun Deng*, Jikai Wen*. AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1. FEBS Journal. 2019 Nov; 286(21): 4215-4231.
3. Shulin Tang, Shuang Chen, Boyan Huang, Jun Jiang, Jikai Wen*, Yiqun Deng*. Deoxynivalenol induces inhibition of cell proliferation via the Wnt/β-catenin signaling pathway. Biochemical Pharmacology. 2019 Aug; 166: 12-22.
4. Ruohong Chen, Jun Jiang, Zhangsheng Hu, Wenchu Ye, Qianqian Yuan, Mengyuan Li, Jikai Wen*, Yiqun Deng*. Coordinated transcriptional regulation of cytochrome P450 3As by nuclear transcription factor Y (NF-Y) and specificity protein 1 (Sp1). Molecular Pharmacology. 2019 May; 95(5): 507-518.
5. Jun Wu#, Sisi Zhu#, Yunbo Wu, Tianqing Jiang, Lingling Wang, Jun Jiang, Jikai Wen, Yiqun Deng*. Multiple CH/π interactions maintain the binding of aflatoxin B1 in the active cavity of human cytochrome P450 1A2. Toxins. 2019 Mar 12; 11(3): 158.
其他代表性论文
1. Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The Ubiquitin Specific Protease USP34 Promotes Ubiquitin Signaling at DNA Double-Strand Breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.
2. Jun Jiang#, Shulin Tang#, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37: 2992-3005.
3. Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*.Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics.2011 Sep; 10(9): M111.008748, 1-18.
4. Shirley M.-H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry. 2011 Jun 24; 286(25): 22355-22361.
主持与参加的科研项目
1. 国家重点研发子课题，2023，主持
2. 广东省自然科学基金面上项目，2023，主持
3. 国家自然科学基金联合基金，2024，参与
4. 区域联合基金-粤港澳研究团队项目，2022，参与
入选的人才基金项目
1.广州市科技计划项目珠江科技新星专项，2016
2.广东省高等学校优秀青年教师培养计划，2015
3.广东省高等学校“千百十人才培养工程”第八批校级培养对象，2014
授权发明专利
1.文继开；陈庆梅；张艳；邓诣群；吴骏；蒋珺；胡泰斗；胡章盛；一种基于人铁蛋白的纳米酶及其制备方法，2022.04.08，中国，ZL201810470199.2.
2.邓诣群；汪玲玲；蒋珺；吴骏；母培强；邓凤如；大肠杆菌在降解代谢黄曲霉毒素B1方面的应用，2020-08-07，中国，ZL201810316911.3.
3.邓诣群；汪玲玲；蒋珺；吴骏；母培强；邓凤如；一株高效降解黄曲霉毒素B1的大肠杆菌CG1061，2020-08-07，中国，ZL201810317744.4.
学术兼职
(1) 中国生物化学与分子生物学会农业分会青年委员会副主任
(2) 广东省生物化学与分子生物学学会青年委员会常务委员
(3) 广东省生物化学与分子生物学学会 理事
(4) 广东省生物物理学会常务理事
学术奖励
1.蒋珺(2/10); 饲料中常见霉菌毒素的分子毒理与生物防控, 大北农科技奖奖励委员会, 其他, 其他, 2021(邓诣群; 蒋珺; 文继开; 母培强; 汪玲玲; 吴骏; 林如琴; 陈庆梅; 邓凤如; 孙峪) (科研奖励)
